产品编号：

C10137

产品名称：

Catalase

CAS:

9001-05-2

储存条件

粉末

-20℃

四年

分子式：

～250KDa

溶于液体

-80℃

六个月

分子量

-20℃

一个月

化学名：

Ethyl p-hydroxybenzoate

Solubility (25°C)：

体外:

DMSO

< 1mg/mL (insoluble or slightly soluble)

Ethanol

Water

33.33mg/mL (Need ultrasonic)

体内(现配现用):

＜1mg/ml表示微溶或不溶。

灏天启生物提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

产品描述

Catalase 是重要的抗氧化酶,在清除 ROS。在维持氧化还原状态的平衡⽅⾯发挥着重要作⽤。Catalase 与肿瘤的发⽣,发 展关系密切。有潜⼒⽤于肿瘤的预防研究。

体外研究

Catalase, the enzyme that metabolizes H2O2 but also reacts with a multitude of other substrates. The active site of catalase contains an iron atom. Human catalase contains four identical subunits, each subunit containing four distinct domains and one prosthetic heme group. The four domains include: (1) a N-terminal arm which contains a distal histidine, an essential amino acid for the catalase reaction; (2) a β-barrel domain that contains eight β-barrels arranged in an antiparallel fashion with six α-helical insertions, conferring the hydrophobic core of the protein necessary for the tri-dimensional structure of the enzyme; (3) a connection domain which contains the tyrosine residue that binds the heme group; and finally (4) an α-helical domains, which is important for NADPH binding